Principal Scientist Immunology, Cellular and Molecular Analytics US at GSK in Rockville, MD

A career in Boston – main video (youtube.com)

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK’s long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

In the plan to create a new hub for mRNA-based vaccines in Cambridge, we are building new laboratories that will be focused on mRNA state-of-the-art platforms that will enable the discovery and early development of new products including deep product understanding, novel delivery systems and advanced characterization at preclinical as well as clinical stages, supporting the introduction of new mRNA-based vaccines.

The new Immunology, Cellular and Molecular Analytics US platform will be composed of three analytical technology platforms in the US: the antibody-based assay group, the cell-based assay group and the nucleic-acid-technology (NAT)-based assay group. The Immunology, Cellular and Molecular Analytics US platform is an integral part of the global analytical platforms based in Belgium and Italy, where method development, qualification and validation as well as GMP activities (release and stability) are executed.

The role of Principal Scientist Immunology, Cellular and Molecular Analytics US is expected to lead, design and execute scientific studies in support of technical programs as they progress from development into early clinical Phases. The candidate will therefore ensure implementation of innovative and cutting-edge analytical methods combining all three technologies and technologies for mRNA and macromolecule (proteins) characterization and testing in line with Quality by Design (QbD) principles in the area of immunology, cellular and molecular biology (FACS, ELISA, Luminex, Octect, (RT)-qPCR and related microfluidic and digital technologies, Next Generation Sequencing (2nd and 3rd generations), direct nucleic acid detection (CRISPR/Cas, NanoString, QuantiGene, etc.).

The candidate will participate to experimental activities according to defined priorities and is responsible for the quality of data and presentation of results to internal and external audiences.
The candidate may manage a small team.

The candidate is also expected to spend few months (from 3 to 6 months) within the first year in Rockville (Washington DC area) to support and ensure a smooth transition of the methods and the knowhow to the new laboratories in Cambridge.

Key Responsibilities:

Be part and an active member of a High-Performing Team of top scientists driven by innovation, quality and excellence.
Cultivate department culture: excellence in science and operations, embracing an open global mindset, fostering a positive culture of transparency and collaboration within the global organization.
Deliver expectations for the following missions:
Develop next generation analytical methods for next generation mRNA vaccines using innovative immuno-based, cell-based and NAT-based technologies and automation in collaboration with the other teams of the global analytical platforms.
Apply these methods to early mRNA candidate vaccines in close collaboration with Preclinical, Drug Substance (DS) and Drug Product (DP) teams for deep product understanding, process development support at the preclinical, DS and DP stages.
Excel in delivering quality data and sound science to drive decisions for new vaccine candidate projects, as part of end-to-end accelerated vaccine CMC development programs.
Design and drive the development of innovative analytical methods for vaccine early development phases and integrate it into the end-to-end CMC strategy. Collaborate closely with the Preclinical, Drug Substance and Drug Product departments, as well as with the other ARDS platforms and other stakeholders to ensure timely delivery.
Act as a key subject matter expert: think out-of-the-box, using sound science, paying attention to details to continuously improve and shape the CMC strategy & framework.
Additional Responsibilities:
Participate to and lead the transfer of developed analytical methods within ARD groups (different sites) or other external partners.
Analyse, interpret and communicate scientific data effectively within Technical R&D including Technical Development Team and be able to defend scientific and technical decisions at the appropriate technical board.
Author and review technical documents in support of various project development stages. Makes sound scientific/technical and business decisions based on a balance of data, analysis and experience.
Benchmark specific technologies in own functional area to bring innovation and technology to state of the art. Identify opportunities to apply new techniques to address project challenges. Contributes to and drives strategy and technical development planning and accountability in the execution thereof.
Act as a voice and ambassador of its department at various internal and external governance bodies and meetings.

Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:

PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related scientific field with an additional 3+ years of post-doc or industry experience in the field.
Total education and experience of 8+ years in analytical sciences in the vaccine field.
Two years or more experience in immuno-based, cell-based and NAT-based technologies.

Preferred Qualifications:

A good understanding of biopharma / vaccine development process.
Strong experience and understanding of molecular biology and analytical development.
Fluency in English.
Experience developing and implementing strategies with measurable outcomes.
Has worked in a multi-disciplinary team, demonstrates skills in combining different analytical technologies (immuno-cellular, cellular-molecular, immuno-molecular) in the field.
Good understanding of QbD principles. Driven by excellence, creativity, accountability, and flexibility in a collaborative and innovative environment.
Capacity to synthesize messages and ability to defend scientific and technical decisions to have constructive interactions and take the right decisions with other Leaders.
Must have the ability to work with cross-functional teams.
Superlative presentation skills, across lines and levels and with senior stakeholders.
Problem-solving ability with limited information available to make decisions and interpretations.
Anticipates medium/long-term future issues.
Positive, open and can-do mindset.
Critical thinking ability is a must.

#Vx-Cam
#Li-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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A career in Boston – main video (youtube.com)

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

The candidate will participate to experimental activities according to defined priorities and is responsible for the quality of data and presentation of results to internal and external audiences.The candidate may manage a small team.

The candidate is also expected to spend few months (from 3 to 6 months) within the first year in Rockville (Washington DC area) to support and ensure a smooth transition of the methods and the knowhow to the new laboratories in Cambridge.

Key Responsibilities:

Be part and an active member of a High-Performing Team of top scientists driven by innovation, quality and excellence.

Cultivate department culture: excellence in science and operations, embracing an open global mindset, fostering a positive culture of transparency and collaboration within the global organization.

Deliver expectations for the following missions:

Develop next generation analytical methods for next generation mRNA vaccines using innovative immuno-based, cell-based and NAT-based technologies and automation in collaboration with the other teams of the global analytical platforms.

Apply these methods to early mRNA candidate vaccines in close collaboration with Preclinical, Drug Substance (DS) and Drug Product (DP) teams for deep product understanding, process development support at the preclinical, DS and DP stages.

Excel in delivering quality data and sound science to drive decisions for new vaccine candidate projects, as part of end-to-end accelerated vaccine CMC development programs.

Act as a key subject matter expert: think out-of-the-box, using sound science, paying attention to details to continuously improve and shape the CMC strategy & framework.

Additional Responsibilities:

Participate to and lead the transfer of developed analytical methods within ARD groups (different sites) or other external partners.

Analyse, interpret and communicate scientific data effectively within Technical R&D including Technical Development Team and be able to defend scientific and technical decisions at the appropriate technical board.

Author and review technical documents in support of various project development stages. Makes sound scientific/technical and business decisions based on a balance of data, analysis and experience.

Act as a voice and ambassador of its department at various internal and external governance bodies and meetings.

Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:

PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related scientific field with an additional 3+ years of post-doc or industry experience in the field.

Total education and experience of 8+ years in analytical sciences in the vaccine field.

Two years or more experience in immuno-based, cell-based and NAT-based technologies.

Preferred Qualifications:

A good understanding of biopharma / vaccine development process.

Strong experience and understanding of molecular biology and analytical development.

Fluency in English.

Experience developing and implementing strategies with measurable outcomes.

Has worked in a multi-disciplinary team, demonstrates skills in combining different analytical technologies (immuno-cellular, cellular-molecular, immuno-molecular) in the field.

Good understanding of QbD principles. Driven by excellence, creativity, accountability, and flexibility in a collaborative and innovative environment.

Capacity to synthesize messages and ability to defend scientific and technical decisions to have constructive interactions and take the right decisions with other Leaders.

Must have the ability to work with cross-functional teams.

Superlative presentation skills, across lines and levels and with senior stakeholders.

Problem-solving ability with limited information available to make decisions and interpretations.

Anticipates medium/long-term future issues.

Positive, open and can-do mindset.

Critical thinking ability is a must.

#Vx-Cam#Li-GSK

The candidate will participate to experimental activities according to defined priorities and is responsible for the quality of data and presentation of results to internal and external audiences.
The candidate may manage a small team.

Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:

#Vx-Cam
#Li-GSK