Job Description

Position Description

We are seeking a creative, self-motivated computational chemist with exceptional interpersonal and problem-solving skills to join the Modeling and Informatics (M&I) department in Boston, MA, US. M&I is a diverse and inclusive team of approximately 50 computational chemists, cheminformaticians, data scientists and machine learning specialists who employ state of the art capabilities to drive drug design. We are an integral arm of both discovery and process chemistry and collaborate seamlessly with teams across the globe to innovate and invent better molecules faster. We are looking for a strategic thinker and accomplished computational drug hunter to take on a position that carries significant influence across our Company chemistry from target identification through delivery of clinical candidates.

Key responsibilities will include:

Scientific Innovation:

• Leading and defining the in-silico strategy on multiple interdisciplinary discovery projects, design and optimize compounds using advanced computational techniques

• Analyzing novel drug targets for tractability using drugability assessment, prioritize targets and help define screening and modality strategies

• Functioning as a subject matter champion for ligand- and structure-based drug design across discovery teams

• Advancing our modeling capabilities through invention, implementation and application of new methodologies

Strategy:

• Leading strategic efforts to enable our future vision for Modeling and Informatics in chemistry

• Enabling a design-driven and predict-first culture throughout our Company's Chemistry department

• Contributing to our Company's overarching drug discovery strategy

Building Relationships:

• Mentorship and scientific development of M&I staff both locally and across our network

• Building bridges and fruitful collaborations with stakeholders across medicinal chemistry, pharmacokinetics & pharmacodynamics, quantitative biosciences, and therapeutic area biology

We recognize that the diversity in our team is our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.

Education Minimum Requirement:

• Ph.D. or M.S. in chemistry, biochemistry, biophysics, or equivalent with a computational emphasis

Required Experience and Skills:

• 7+ years of professional experience with a Ph.D., or 9+ years with a M.S.

• Evidence of creative application of computational approaches to problems of pharmaceutical interest

• Strong oral and written communication skills, with a recognized ability to positively influence team decisions

• Ability to communicate, collaborate and deliver results in a fast-paced, global environment and to manage multiple priorities simultaneously

• Ability to see the 'big picture', and identify opportunities for impact now and in the future

• Proficiency in general molecular modeling techniques (docking, molecular simulation, homology modeling, quantum mechanics, QSAR / machine learning, ligand- and structure-based design) with modern software packages (e.g. Schrodinger, OpenEye, CCG)

• Skilled in scientific programming (e.g. Python, Pipeline Pilot) and data analytics (e.g. Spotfire)

Preferred Experience and Skills:

• Desire to lead strategic efforts relevant to drug discovery

• Passion for mentoring scientific staff

#EligibleforERP

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

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Travel Requirements:

Flexible Work Arrangements:

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Job Posting End Date:

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Requisition ID:R331775